Deane has missed the Hammers last three games with an ankle injury but manager Alan Pardew has confirmed the striker will return for the game against North End at Upton Park on Saturday.
"Deano will be available for Saturday and that is big news for us," Pardew told the clubs official website.
"He is going to be an important player for us in this run-in and I am looking forward to having him in the dressing room."